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COMPARISON OF CROSS-SECTIONAL AND LONGITUDINAL FREESURFER PIPELINE FOR ESTIMATION OF FLORBETAPIR PET SUVR MEASUREMENTS

      Longitudinal imaging data has becoming increasingly common in clinical studies of aging and dementia. A procedure that specifically takes longitudinally acquired data into consideration has been developed and implemented in the FreeSurfer package (Reuter 2012), which has demonstrated improved precision and statistical power in detecting longitudinal changes. It is reasonable to assume this finding can be generalized to other quantitative imaging analysis tasks such as positron emission tomography (PET) measurements of amyloid burden. We therefore test this hypothesize using longitudinal florbetapir PET data.
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