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LONGITUDINAL INVESTIGATION OF CONCORDANT AND DISCORDANT AMYLOID CSF/PETBIOMARKERS REVEALS CSF-FIRST AND PET-FIRST PATHWAYS OF AMYLOID ACCUMULATION

      While Florbetapir-PET and CSF-Aβ42 usually provide highly concordant information, mismatch between these measures has been consistently reported in a minority of cases. Here, we tested the hypothesis that discordance is due to differences in amyloid processing and kinetics in the CSF vs. in the brain, whereby CSF represents a dynamic measure of ongoing amyloid accumulation, while PET provides end-stage information on resulting amyloid accumulation. Consequently, we hypothesized that the earliest stage of amyloid deposition consists of isolated CSF+/PET- cases only.
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