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Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany
One of the earliest brain regions affected during the development of Alzheimer’s disease
(AD) is the cholinergic basal forebrain (BF). Especially the posterior part of the
Nucleus basalis Meynert (Ch4p) seems to be affected already during subclinical stages
of AD, leading to early cholinergic depletion. In subjects with subjective cognitive
decline (SCD) as an at-risk population for AD significant volume decreases were reported.
However, the relation between Ch4p volume loss and markers of AD pathology in SCD
is still largely unknown. This study investigated how cortical amyloid status relates
to potential BF volume loss in SCD, specifically whether there are any signs for Ch4p
degeneration in amyloid-positive (SCDAß+) compared with amyloid-negative (SCDAß-) individuals.
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