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CORTICAL AMYLOID BURDEN CORRELATES WITH ATROPHY OF THE POSTERIOR PART OF THE NUCLEUS BASALIS MEYNERT IN AMYLOID-POSITIVE SCD

      One of the earliest brain regions affected during the development of Alzheimer’s disease (AD) is the cholinergic basal forebrain (BF). Especially the posterior part of the Nucleus basalis Meynert (Ch4p) seems to be affected already during subclinical stages of AD, leading to early cholinergic depletion. In subjects with subjective cognitive decline (SCD) as an at-risk population for AD significant volume decreases were reported. However, the relation between Ch4p volume loss and markers of AD pathology in SCD is still largely unknown. This study investigated how cortical amyloid status relates to potential BF volume loss in SCD, specifically whether there are any signs for Ch4p degeneration in amyloid-positive (SCDAß+) compared with amyloid-negative (SCDAß-) individuals.
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