Advertisement

LONGITUDINAL CHANGES IN FUNCTIONAL CONNECTIVITY IN CONVERSION TO SYMPTOMATIC AD

      Low frequency oscillations of resting state fMRI (rs-fc) signal correlate with spontaneous neural activity. These differences have previously been observed in individuals diagnosed with symptomatic Alzheimer’s Disease (AD). The Amyloid – Tau – Neurodegeneration (ATN) framework provides a scheme for classifying AD using several key biomarkers; however, it omits rs-fc. The purpose of this study is threefold: 1. Identify which intranetwork rs-fc connections vary the most between individuals diagnosed with symptomatic AD and healthy individuals. 2. Assess when changes in rs-fc occur relative to symptomatic conversion in AD. 3. Evaluate the relationship between rs-fc and other common AD biomarkers.
      To read this article in full you will need to make a payment
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'