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Washington University in St. Louis School of Medicine, St. Louis, MO, USAWashington University, St. Louis, MO, USAKnight Alzheimer’s Disease Research Center, Saint Louis, MO, USAWashington University School of Medicine, Saint Louis, MO, USA
Low frequency oscillations of resting state fMRI (rs-fc) signal correlate with spontaneous
neural activity. These differences have previously been observed in individuals diagnosed
with symptomatic Alzheimer’s Disease (AD). The Amyloid – Tau – Neurodegeneration (ATN)
framework provides a scheme for classifying AD using several key biomarkers; however,
it omits rs-fc. The purpose of this study is threefold: 1. Identify which intranetwork
rs-fc connections vary the most between individuals diagnosed with symptomatic AD
and healthy individuals. 2. Assess when changes in rs-fc occur relative to symptomatic
conversion in AD. 3. Evaluate the relationship between rs-fc and other common AD biomarkers.
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