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EARLY RESTING-STATE NETWORK DYSFUNCTION IN APOE ε4 CARRIERS WITHOUT BIOMARKER EVIDENCE OF ALZHEIMER’S DISEASE IS RELATED TO SUBCLINICAL TAU CHANGES

      APOE ε4 has been linked to accelerated amyloid deposition and tau-tangle formation. We hypothesized that cognitively normal AD biomarker-negative individuals would exhibit synaptic dysfunction and subsequent resting-state functional connectivity (rs-fc) network disruptions related to the presence of APOE ε4.
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