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EFFECTIVE CONNECTIVITY WITHIN THE LEFT AND RIGHT EXECUTIVE CONTROL NETWORKS IN MCI AND AD

      The default mode network, implicated in various types of memory, is often investigated in Alzheimer’s disease (AD). AD patients often exhibit both memory impairments and executive dysfunction. The executive control network (ECN), thought to be linked with the default mode network and implicated in executive function, differs in functional connectivity, often measured using Pearson correlation, between healthy controls and individuals with AD (Agosta et al., 2012). Differences in effective connectivity, a measure of causal neuronal interaction, as measured using Granger causality were noted between healthy controls, individuals with mild cognitive impairment (MCI), and individuals with AD (Cai et al., 2017). ECN effective connectivity (EC) was explored here using dynamic causal modeling (DCM) to obtain EC at the unobserved neuronal level rather than the observed BOLD signal by accounting for local differences in hemodynamic response.
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