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FUNCTIONAL BRAIN ARCHITECTURE PREDICTS LONGITUDINAL TAU SPREADING IN ALZHEIMER’S DISEASE

      In Alzheimer’s disease (AD), tau pathology emerges in the entorhinal cortex and subsequently spreads throughout the brain. Recent tau-PET studies in AD suggested that higher resting-state fMRI-assessed connectivity predicts higher local tau pathology, suggesting network-specific tau spread. However, evidence for higher connectivity being indeed predictive of faster tau spreading is missing. To address this, we combined longitudinal AV451 tau-PET and resting-state fMRI, to test whether higher inter-regional connectivity predicts faster tau spread in AD.
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