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In Alzheimer’s disease (AD), tau pathology emerges in the entorhinal cortex and subsequently
spreads throughout the brain. Recent tau-PET studies in AD suggested that higher resting-state
fMRI-assessed connectivity predicts higher local tau pathology, suggesting network-specific
tau spread. However, evidence for higher connectivity being indeed predictive of faster
tau spreading is missing. To address this, we combined longitudinal AV451 tau-PET
and resting-state fMRI, to test whether higher inter-regional connectivity predicts
faster tau spread in AD.
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