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DECODING GLUCOSE METABOLISM IN ALZHEIMER’S DISEASE REVEALS MACRO-SCALE BRAIN ORGANIZATION RELATED TO DISEASE EXPRESSION

      Cognition at a macroscale emerges from local interactions. Alzheimer’s disease (AD) results in clinical deficits in cognition through disruption of this emergent global architecture. However, the neurobiology of cognition and AD at the macroscale is poorly understood. In this study, we used global patterns of glucose uptake as an observable feature of macroscale AD pathophysiology. Glucose uptake variability across individuals encodes the macroscale consequence of AD. Parameterization of patterns in glucose uptake decodes this pathophysiology revealing fundamental large-scale axes of functional brain organization and allowing estimation of a global functional state space (GFSS) that captures central features of the neurobiology of AD.
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