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PATTERNS OF INCREASED AND DECREASED PRECUNEUS FUNCTIONAL CONNECTIVITY IN SCD DEPENDING ON AMYLOID STATUS

      The precuneus/posterior cingulate (PCC) is a hub region of the default-mode network (DMN) and a prominent target of amyloid-beta (Aß) deposition in MCI and AD causing subsequent disruptions of DMN functional connectivity (FC). In subjective cognitive decline (SCD), amyloid load effects on posterior DMN FC are less well known. We aimed to compare precuneus FC in SCD with and without amyloid deposition and to disentangle the contributions of regional & global Aß load.
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