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German Center for Neurodegenerative Diseases (DZNE), Tuebingen, GermanySection for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tuebingen, Tuebingen, Germany
The precuneus/posterior cingulate (PCC) is a hub region of the default-mode network
(DMN) and a prominent target of amyloid-beta (Aß) deposition in MCI and AD causing
subsequent disruptions of DMN functional connectivity (FC). In subjective cognitive
decline (SCD), amyloid load effects on posterior DMN FC are less well known. We aimed
to compare precuneus FC in SCD with and without amyloid deposition and to disentangle
the contributions of regional & global Aß load.
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