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WORSENING FUNCTIONAL CONNECTIVITY WITHIN DEFAULT MODE NETWORK IS ASSOCIATED WITH HIGHER AV-1451 PET UPTAKE IN MEDIAL TEMPORAL LOBE

      The accumulation of neurofibrillary tangles contributes to a neurodegenerative cascade toward Alzheimer’s Disease. Focal sites of tau pathology may impair signal integrity within a broader network of functionally-connected brain regions. 18F-AV1451 PET allows in-vivo visualization of tau pathology, while functional MRI reveals connectivity within resting-state networks. We sought to assess the relationship of worsening functional connectivity to tau burden.
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