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The accumulation of neurofibrillary tangles contributes to a neurodegenerative cascade
toward Alzheimer’s Disease. Focal sites of tau pathology may impair signal integrity
within a broader network of functionally-connected brain regions. 18F-AV1451 PET allows
in-vivo visualization of tau pathology, while functional MRI reveals connectivity
within resting-state networks. We sought to assess the relationship of worsening functional
connectivity to tau burden.
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