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A STRATEGIC HUMAN-BASED ADRD RESEARCH PROGRAM: TOWARD BASIC MECHANISM DISCOVERY, THERAPEUTIC TRANSLATION, PUBLIC POLICY, EDUCATION AND HEALTH

      Despite repeated announcements of breakthroughs in Alzheimer's disease and related dementias (ADRD) research, the stark reality remains that there have been no substantial advancements in treatments. These failures in clinical translation are in large part due to a systemic dependence on a flawed framework based on validating preclinical findings using animal experimentation. In particular, researchers are repeatedly incentivized by funding programs toward dominant reductionist frameworks (e.g., amyloid-, tau-centric) and xenogenic research (e.g., transgenic and chimeric models). Here we present an integrated program of impact studies, research protocols and policy proposals that aim to address the stagnation in ADRD research, ethical issues and clinical outcomes by advancing new multi-scale human-based approaches.
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